Central to the differentiation and patterning of the Drosophila oocyte is the asymmetric intracellular localization of numerous mRNA and protein molecules involved in developmental signalling. Recent advances have identified some of the molecules mediating oocyte differentiation, specification of the anterior pole of the embryo, and determination of the embryonic germ line. This work is considered in the context of the classical model of the germ plasm as a cytoplasmic determinant for germ cell formation.

An authoritative account of the intellectual and educational history of the late Italian Renaissance. Twenty essays on major themes, institutions, and persons of the Italian Renaissance by one of its most distinguished living historians.

The Pasadena game invented by Nover and Hájek raises a number of challenges for decision theory. The basic problem is how the game should be evaluated: it has no expectation and hence no well-defined value. Easwaran has shown that the Pasadena game does have a weak expectation, raising the possibility that we can eliminate the value gap by requiring agents to value gambles at their weak expectations. In this paper, I first prove a negative result: there are gambles like the (...) Pasadena game that do not even have a weak expectation. Hence, problematic value gaps remain even if decision theory is extended to take in weak expectations. There is a further challenge: the existence of a ‘value gap’ in the Pasadena game seems to make decision theory inapplicable in a number of cases where the right choice is obvious. The positive contribution of the paper is a theory of ‘relative utilities’, an extension of decision theory that lets us make comparative judgements even among gambles that have no well-defined value. (shrink)

What kind of thing are we? Paul Snowdon's answer is that we are animals, of a sort. This view--'animalism'--may seem obvious but on the whole philosophers have rejected it. Snowdon argues that animalism is a defensible way of thinking about ourselves. Its rejection rests on the tendency when doing philosophy to mistake fantasy for reality.

The author first examines the usefulness of argument by analogy in moral discussions, the way argument by analogy works and three ways in which it can miscarry. He then uses this understanding of argument by analogy to see if the conceptionalists' position on the emergence of the value of life, on which rests their opposition to virtually all direct abortion, can be illumined and strengthened by analogies drawn from our other experiences of the emergence of value. The fact that no (...) such analogies can be located is presented as a significant, but not necessarily fatal obstacle to the understanding and the acceptance of the conceptionalist position. (shrink)

Professor Honderich presents his account of consciousness boldly and informally, and his presentation merits a response in similar terms. I conceive of this response as simply the first move in a conversation, in the course of which misunderstandings might be removed and, just possibly, criticisms sharpened, and positions modified. I want to concentrate on two questions that his very interesting paper prompts me to ask. The first question is; what exactly is the thesis about consciousness that Professor Honderich is proposing? (...) The second question is; what are the main reasons he has for his proposal and are they persuasive? Although there are two questions, I shall mix considerations of them together in a way which I hope it is possible to follow. (shrink)

We should seek an ethic internal to marketing arising from marketing's societal function, rather than imposing some add-on ethic. This suggests that marketing should enhance the information and the freedom the potential customer brings to the market transaction. Defining and achieving this information and freedom is difficult, but marketers suggest that the market itself drives out major violators, a suggestion less persuasive concerning increasingly complex goods and services. Marketing also is tempted to appeal to our baser, darker side. These problems (...) are better addressed through self-regulation guided by a vision of advertising and business in the service of society, and by the marketer's own sense of integrity than through external regulation. (shrink)

The authors argue that the time is ripe for national and corporate leaders to move consciously towards the development of global ethics. This papers presents a model of global ethics, a rationale for the development of global ethics, and the implications of the model for research and practice.

Professor Donaldson in his book Corporations and Morality has attempted to use a social contract theory to develop moral principles for regulating corporate conduct. I argue in this paper that his attempt fails in large measure because what he refers to as a social contract theory is, in fact, a weak functionalist theory which provides no independent basis for evaluating business corporations. I further argue that given the nature of a morality based on contract and the nature of the modern (...) corporation, it is highly unlikely that any plausible contract theory of business ethics can be developed. (shrink)

This article provides a critical examination of a controversial issue that has theoretical and practical importance to a broad range of academic disciplines: Are religious experiences localized within the brain? Research into the neuroscience of religious experiences is reviewed and conceptual and methodological challenges accompanying the neurotheology project of localizing religious experiences within the brain are discussed. An alternative theory to current reductive and mechanistic explanations of observed mind–brain correlations is proposed — a mediation theory of cerebral action — that (...) has the potential for addressing what Chalmers called the “hard problem” of consciousness. (shrink)

The trilogy is viewed through the lens of myth and metaphor. A wide variety of philosophical and mythological themes are presented and expounded upon, drawing from a rich source of scholars, thinkers, writers, and poets from East and West alike. Heretical or not, the Star Wars prequels are a surprisingly rich source of insight into the whole saga.

Gift and gratitude are examined as moral realities and are found to play a variety of roles in the moral life and in moral discourse. Some of these have to do with obligations arising from the gift relation while others stand in some tension with the idea of obligation. The relation between these two kinds of elements is explored. Gift and gratitude are also examined in relation to moral agenthood. The analysis is then tested for its usefulness in relation to (...) some problematic gifts cited in Christian ethics. Finally, some normative implications of the analysis are briefly suggested. (shrink)

This text gives business students a sense that problems of business policy can be resolved, in part, by ideas from philosophy, social theory, and law. It enables students to view ethical principles as a response to an evolving set of problems related to harmonizing values in a pluralistic society.

The view that female mammals are more docile appears to arise in part from imposing human values on animal studies. Many reports of sexual dimorphism in physical aggression favouring the male in laboratory rodents appear to select circumstances where that expectation is supported. Other situations that favour the expression of conflict in females have been (until recently) relatively little studied. Although female rodents generally do not show the “ritualised” forms of conflict that characterise male sexual competition, they can use notably (...) damaging strategies (especially if they are of short duration). Such considerations might weigh in the selection of strategies by our own species. (shrink)

The ability to imagine hypothetical events in one’s personal future is thought to involve a number of constituent cognitive processes. We investigated the extent to which individual differences in working memory capacity contribute to facets of episodic future thought. College students completed simple and complex measures of working memory and were cued to recall autobiographical memories and imagine future autobiographical events consisting of varying levels of specificity . Consistent with previous findings, future thought was related to analogous measures of autobiographical (...) memory, likely reflecting overlapping cognitive factors supporting both past and future thought. Additionally, after controlling for autobiographical memory, residual working memory variance independently predicted future episodic specificity. We suggest that when imagining future events, working memory contributes to the construction of a single, coherent, future event depiction, but not to the retrieval or elaboration of event details. (shrink)